Just be careful with it - it does have cautions. Notes on Juglone
"The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblasts.
Juglone (5-hydroxy-1,4-naphtoquinone) is a natural toxin
produced by walnut trees. In this study we show that juglone differentially reduces viability of human cells in culture.
Our results show that juglone
has multiple effects on cells such as the induction of DNA damage, inhibition of transcription, reduction of p53 protein levels and the induction of cell death." http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=162716 20&dopt=Abstract "Black Walnut Toxicity
The largest concentrations of juglone
and hydrojuglone (converted to juglone by sensitive plants) occur in
the walnut's buds, nut hulls
, and roots. However, leaves and stems do contain a smaller quantity." http://www.wvu.edu/~agexten/hortcult...s/blkwalnt.htm
"The bad news is that the only biologically active compound unique to walnut trees is not a good medication
: it kills plants, poisons other mammals, and is less efficacious as a therapeutic than other drugs. Walnut trees
contain a toxin called Juglone
, which is a naphthaquinone found in all parts of plants of the walnut family
Although Juglone has not been proven acutely toxic in humans
, walnut trees pose an allergic threat to many people.
To sum up, extracts from walnut trees, or any members of the Juglandaceae family, are useful for many things, but not for medications
, since juglone is potentially toxic
and raw extracts are potentially allergenic. Fortunately, there is no juglone present in the fruits of these trees, so walnuts and pecans are a healthy and delicious addition to foods, which makes them agriculturally valuable." http://www.madsci.org/posts/archives...1900.Me.r.html "Adverse Reactions
Allergic reactions to black walnut in animals and humans have occurred. 17
Allergy studies involving skin testing with black walnut pollen (and other pollens) finds moderate allergic reactions in certain individuals. 18 Reports on dermatitis from black walnut 19 , 20 and on E. coli in black walnut 21 are available
Black walnut is contraindicated in pregnancy because of possible cathartic effects at higher doses and in patients with chronic disease of the GI tract. 22
, 23 Toxicology Juglone
, the naphthaquinone found in black walnut and many others in the family Juglandaceae, is regarded as a toxin." http://www.drugs.com/npp/black-walnut.html
"Black Walnut Juglans nigra Summary
When taken by mouth, black walnut may have some effectiveness for gastrointestinal ailments. Chemicals in black walnut products may shrink skin and mucosal tissue, making them useful for mouth sores and skin conditions such as ringworm or wounds. Risks
Individuals with intestinal, liver, or stomach conditions should not use black walnut due to its possible irritating effects. Women who are pregnant or breast-feeding and small children should also avoid using black walnut. Side Effects
Liver or kidney damage and some types of oral cancer may be more likely to affect individuals who take large doses of products, like black walnut, that have a high content of chemicals known as tannins for long periods of time. Potentially, tannin-containing products can cause stomach upset when taken by mouth. They may also irritate damaged skin when applied topically. Interactions
No specific interactions have been identified between black walnut and prescription drugs, non-prescription drugs, other supplements, or foods.
However, because few reliable studies of black walnut have been conducted
, it may have interactions with drugs, foods, and other dietary supplements. Other oral products that contain tannins have interfered with the way the body uses certain drugs. Be sure that your doctor and pharmacist are aware of all the prescription and non-prescription medicines you take before you begin to use black walnut or any other herbal supplement." http://www.drugdigest.org/DD/Printab...5,4080,00.html